BCR gene : BCR (Gene) - an overview

BCR gene

20 Sep 2024 —

This gene is the ABL1 gene of chromosome 9 juxtaposed onto the breakpoint cluster region BCR gene of chromosome 22, coding for a hybrid protein: a tyrosine .... 由 N Sharma 著作 · 2015 · 被引用 47 次 — Chronic Myeloid Leukaemia (CML) is caused by the BCR/ABL1 fusion gene. Both the presence and the levels of BCR/ABL1 expression seem to be .... BCR activator of RhoGEF and GTPase [Source:HGNC Symbol;Acc:HGNC:1014].

Gene Synonyms. ALL, BCR1, CML, D22S11, D22S662, PHL.

Location.. The BCR protein inactivates a GTPase known as Rac1 by stimulating a reaction that turns the attached GTP into GDP. Through this activity, the ....

Since the first discovery of a fused kinase-encoding gene, BCR-ABL, which is encoded by the so-called “Philadelphia chromosome” of chronic myeloid leukemia (CML) ....